Журнал генетических расстройств и генетических отчетов

Involvement of TLR4 Polymorphisms on Colorectal Cancer Treatment

Omrane I, Baroudi O, Medimegh I, Ayari H,  Kourda N, Mezlini A, Bougatef  K and Benammar-Elgaaied A

The important role of polymorphisms on immunity genes in the susceptibility to various diseases has been widely described. Both polymorphisms D299D and T399I of TLR4 are shown associated with inflammatory bowel diseases as well as colorectal cancer. Previously, we have shown that TLR4 polymorphisms are significantly associated with disease presentation of colorectal cancer such as late stage, differentiation as well as lymph, node and metastasis.  Our study aimed to investigate an association between TLR4 D299G and T399I polymorphisms in Tunisian patients with colorectal cancer treatment. We found that T399I and D299G polymorphism of TLR4 were significantly associated with adjuvant chemotherapy and radical surgery. We also showed that mutant alleles of T399I and D299G combined genotypes and haplotypes may affect the effectiveness of therapy. Finally, we showed no significant longer survival and TLR4 polymorphisms. In conclusion, we suggest that polymorphisms in TLR4 gene may be predictive of treatment type.