Журнал регенеративной медицины

Clinical Significance of Tissue Engineering Methods

Robin Murray*

To create bioartificial organ and tissue substitutes using the tissue engineering (TE) paradigm, engineering and life sciences tools are combined. These bioartificial substitutes can then be used in regenerative medicine, pharmaceutical, diagnostic, and basic research to elucidate fundamental facets of cell functions in vivo or to pinpoint mechanisms underlying ageing processes and the onset and progression of disease. Interactions between various cell types and the extracellular matrix, whose makeup changes depending on the tissue, level of maturity, and health circumstances, are made possible by the intricate three-dimensional (3D) milieu in which cells are structured in vivo.Overcoming the well-known limitations of organ transplantation, TE seeks to trigger tissue-specific regeneration mechanisms (i.e., donor shortage, need of immunosuppressive therapy). In vitro models of healthy or sick tissues and organs that may be used for drug testing, the assessment of novel therapeutics, and the exploration of the intricate processes governing the genesis and progression of illness have recently been proposed using TE methods. These models not only have a strong scientific potential but also have certain advantages in terms of moral and financial matters.