Журнал нефрологии и заболеваний почек

Angiotensin

Kalyan Kumar

Angiotensin is a peptide endocrine chemical and a significant piece of the renin-angiotensin-aldosterone framework, a between related endocrine framework significant in volume and pulse control. Angiotensinogen, an alpha-globulin, and the peptide prohormone is orchestrated principally by the liver and circles in plasma. At the point when pulse drops, or when thoughtful signs arrive at the kidney, renin, a peptide delivered basically by the renal juxtaglomerular cells, is delivered and enzymatically separates off two amino acids shaping angiotensin I (ATI), a decapeptide. ATI is additionally severed into an octapeptide, angiotensin II (ATII) by the activity of angiotensin-changing over catalyst (ACE), basically in the aspiratory endothelium, however this compound is available in the endothelium of different organs including the heart. ATII is an intense vasopressor, following up on vascular endothelial receptors. The two sorts of ATII receptors present in the heart and vasculature smooth muscle that are answerable for signal transduction in intervening the vasoconstrictive activity of ATII are the AT1 and AT2 receptors. Their flagging prompts calciumsubordinate phosphorylation of myosin, which prompts compression of the vascular smooth muscle. This blood vessel smooth muscle withdrawal is answerable for raising blood pressure… Additionally, ATII communicates with AT receptors at different destinations in the nephron to animate sodium reabsorption. ATII likewise follows up on the zona glomerulosa of the adrenal cortex to animate the arrival of aldosterone, a steroid chemical that follows up on the kidney to advance sodium and water maintenance. Angiotensinchanging over chemical inhibitors (ACEI) may expand the impact of IV angiotensin II, and the utilization of angiotensin receptor blockers (ARB) may lessen the impact of IV angiotensin II. The component for the connection with ACEIs isn’t indicated. The connection with ARBs is by pharmacodynamic opposition of the medication at the receptor site.