Журнал печени: болезни и трансплантация

Warburg effect on liver

Lakshmi Vasudha Yirrinki

We found that the Warburg result was exaggerated in liver metastatic tumor lesions in rats. PKM2 and p-STAT3 were upregulated in activated oval cells in liver metastatic tumor lesions in rats. The Warburg result, p-PKM2, and p-STAT3 expression were conjointly exaggerated in reworked WB-F344 cells. In medicine, the Warburg result is that the observation that the majority cancer cells preponderantly turn out energy by a high rate of metabolism followed by carboxylic acid fermentation within the cytoplasm, instead of by a relatively low rate of metabolism followed by oxidization of pyruvate in mitochondria as in most traditional cells.