Ла Пренса Медика

Hepatoprotective activity of Herbadict tablet: An ayurvedic herb mineral product on alcohol induced mortality and liver lesions in mice

Badekila Sathyanaray

The main objective is to study the possible protective effects of Herbadict tablet, a polyherbal ayurvedic product against alcoholinduced mortality and liver lesions in mice. Healthy female Swiss albino mice were divided into six groups containing 8 animals each. Herbadict tablet was suspended in 0.5% Carboxy Methyl Cellulose (CMC) and administered at two doses i.e., 30 mg/kg and 100 mg/kg body weight. Vehicle control, positive control and reference
control (Silymarin) were used for comparison. Alcoholic intoxication was induced using ethanol. Treatment with Herbadict significantly (p<0.01) decreased SGOT, SGPT and -GT at 100 mg/kg when compared to the vehicle treated alcohol intoxicated group. A dose dependent significant decrease in total bilirubin was observed at 30 and 100 mg/kg of Herbadict when compared to vehicle treated alcohol intoxicated group. Treatment with Herbadict at 30 and 100mg/kg p.o. showed hepatoprotective effect against alcohol induced
damage in mice model.