Dinesh M Pardhi, Herida Regina Nunes Salgado, Sumitra Nain
Evaluation of the Potential of Natural Biodegradable Polymers (Echinochloa Colonum Starch) and its Derivatives in Aqueous Coating of Hydrophilic Drugs
The two starch derivatives viz. acetyl starch and Carboxymethylated starch (CMS) were prepared in the laboratory. These derivatives and starch evaluated for their film forming and coating properties. The Metformin Hydrochloride, Acetyl Salicylic Acid, Ascorbic Acid were selected as model drugs as they are moisture sensitive for the preparation of core tablets. The prepared core tablets were coated with Echinochloa colonum pure starch, its acetyl and carboxy methyalted derivative. Physical properties viz., microscopy, swelling capacity, bulk density, tapped density, packing fraction of Echinochloa colonum were better than its other derivatives. Amylase content and film characteristics of pure starch were better. The coated tablets were evaluated for mechanical and chemical properties. It was observed that Carboxymethylated starch of Echinochloa colonum successfully sustained the drug release above 10 hours with excellent mechanical and chemical properties.
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